How much does ductwork replacement cost?

The short answer
Typical: $3,000–$7,000 for most homes.
The full picture

Full duct replacement in an average home runs $3,000–$7,000. Larger homes, hard-to-reach attics, or upgrades to sealed/insulated ducts push higher. Ductwork is the #1 hidden cost in 'cheap' system quotes.

What drives the price

Red flags in a quote

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Typical US ranges; your market varies. Always get 2–3 competing quotes.